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The first vaccine to be registered against COVID-19 in the world3, with confirmed efficacy of 91.6%.1
How do vaccines work?5
There are three main approaches to designing a vaccine. Their differences lie in whether they use a whole virus or bacterium; just the parts of the germ that triggers the immune system; or just the genetic material that provides the instructions for making specific proteins and not the whole virus.
Step 1
A vaccine is a tiny weakened non-dangerous fragment of the organism and includes parts of the antigen
A vaccine is a tiny weakened non-dangerous fragment of the organism and includes parts of the antigen
Step 2
It’s enough that our body can learn to build the specific antibody
It’s enough that our body can learn to build the specific antibody
Step 3
Then if the body encounters the real antigen later, as part of the real organism, it already knows how to defeat it.
Then if the body encounters the real antigen later, as part of the real organism, it already knows how to defeat it.
How does Sputnik V work?4
The use of two vectors is a unique technology of the Gamaleya Center making the Russian vaccine different from other adenovirus vector-based vaccines being developed globally
Vector creation
A vector is a virus that lacks a gene responsible for reproduction and is used to transport genetic material from another virus that is being vaccinated against into a cell.
The vector does not pose any hazard to the body. The vaccine is based on an adenovirus vector which normally causes acute respiratory viral infections.
A gene coding S protein of SARS-COV-2 is inserted into each vector. The spikes form the “crown”. The SARS-COV-2 virus uses spikes to get into a cell.
1st vaccination (component-1)
Vector with a gene coding S protein of coronavirus gets into a cell. The body synthesises S protein in response, the production of immunity begins.
2nd vaccination (component-2)
Repeated vaccination takes place in 21 days. The vaccine based on another adenovirus vector unknown to the body boosts the immune response and provides for long lasting immunity
Advantages of prime-boost immunisation approach
Confirmed efficacy of
91.6%1
Authorised in more than
65 countries 2
with a total population of over 3.2 billion people
Clinical trials on human adenovirus based vector vaccines began as early as
1990s6
Frequently asked questions about Sputnik V
What you need to know before you use Sputnik V?
Tell your healthcare provider about all of your medical conditions, including:
- If you have kidney or liver problems, severe disorders of the endocrine system (diabetes mellitus), severe diseases of the hematopoietic system, epilepsy, strokes and other diseases of the central nervous system,
- If you have diseases of the cardiovascular system (history of myocardial infarction, myocarditis, endocarditis, pericarditis, ischemic heart disease),
- If you have primary and secondary immunodeficiency, autoimmune diseases,
- If you have lung diseases, asthma and COPD, with allergic reactions, atopy, eczema,
- If you are pregnant or plan to become pregnant,
- If you have any other serious illnesses,
- If you are taking any medicines (prescription, over-the-counter, vitamins, or herbal products).
You should consult your healthcare provider before deciding to take the vaccine.
- If you have kidney or liver problems, severe disorders of the endocrine system (diabetes mellitus), severe diseases of the hematopoietic system, epilepsy, strokes and other diseases of the central nervous system,
- If you have diseases of the cardiovascular system (history of myocardial infarction, myocarditis, endocarditis, pericarditis, ischemic heart disease),
- If you have primary and secondary immunodeficiency, autoimmune diseases,
- If you have lung diseases, asthma and COPD, with allergic reactions, atopy, eczema,
- If you are pregnant or plan to become pregnant,
- If you have any other serious illnesses,
- If you are taking any medicines (prescription, over-the-counter, vitamins, or herbal products).
You should consult your healthcare provider before deciding to take the vaccine.
Who should not get the Sputnik V vaccine?
If you have:
- Hypersensitivity to any component of a vaccine or a vaccine containing similar components,
- History of severe allergic reactions,
- If you are suffering from common cold, runny nose, fever, cough, body ache or loose motions etc,
- If you are pregnant,
- Age up to 18 years (due to lack of data on efficacy and safety),
- Developed severe post-vaccination complications (anaphylactic shock, severe generalized allergic reactions, convulsive syndrome, temperature above 40°C, etc.) for the injection of component I of the vaccine.
- Hypersensitivity to any component of a vaccine or a vaccine containing similar components,
- History of severe allergic reactions,
- If you are suffering from common cold, runny nose, fever, cough, body ache or loose motions etc,
- If you are pregnant,
- Age up to 18 years (due to lack of data on efficacy and safety),
- Developed severe post-vaccination complications (anaphylactic shock, severe generalized allergic reactions, convulsive syndrome, temperature above 40°C, etc.) for the injection of component I of the vaccine.
What if I miss the second dose?
If you forget to go back at the scheduled time, ask your healthcare provider for advice.
What are the side effects of the Sputnik V vaccine?
Side effects that have been reported with the SPUTNIK V Vaccine include:
Very common (may affect more than 1 in 10 people):
- Tenderness, pain, warmth, redness, itching, swelling or bruising where the injection is given.
- Flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills.
Common (may affect 1 in 10 people):
- Headache
- Feeling tired
- Feeling feverish or chills
- Muscle pain
- Runny nose
- Cough
Uncommon (may affect upto 1 in 100people):
- Feeling sick (Nausea)
- Being sick (Vomiting)
- Stomach ache
- Joint pain
- Decrease appetite
- Sore throat
- Nasal congestion
- Impaired sense of taste
- Doubtfulness
These may not be all the possible side effects of the SPUTNIK V Vaccine.
Serious and unexpected side effects may occur. SPUTNIK V Vaccine is still being studied in clinical trials and follow up on the trials is going on.
Very common (may affect more than 1 in 10 people):
- Tenderness, pain, warmth, redness, itching, swelling or bruising where the injection is given.
- Flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills.
Common (may affect 1 in 10 people):
- Headache
- Feeling tired
- Feeling feverish or chills
- Muscle pain
- Runny nose
- Cough
Uncommon (may affect upto 1 in 100people):
- Feeling sick (Nausea)
- Being sick (Vomiting)
- Stomach ache
- Joint pain
- Decrease appetite
- Sore throat
- Nasal congestion
- Impaired sense of taste
- Doubtfulness
These may not be all the possible side effects of the SPUTNIK V Vaccine.
Serious and unexpected side effects may occur. SPUTNIK V Vaccine is still being studied in clinical trials and follow up on the trials is going on.
Can I receive the Sputnik V vaccine with other vaccines?
There is no information on the use of the SPUTNIK V Vaccine with other vaccines.
What if I am pregnant or breastfeeding?
The product is not for use during pregnancy, since its effectiveness and safety during this period have not been studied. Gam- COVID- Vac can be administered safely in lactating women.
Can the Sputnik V vaccine give me COVID-19 infection?
No. The Sputnik V COVID-19 vaccine does not contain SARS-CoV-2 and cannot give you COVID-19 infection.
Sputnik V vaccine in the news
Sputnik V announcements and events
Important information about availability of Sputnik V vaccine.
07th September, 2021
For information about the availability of the Sputnik V vaccine, please visit http://bit.ly/Sputnik-vaccine.
Statement from Dr. Reddy’s Laboratories on the Sputnik V vaccine in India
12th July, 2021
Dr. Reddy’s Laboratories issues a statement about the Sputnik V vaccine in India.
Update on the Sputnik V vaccine in India
16th June, 2021
Dr. Reddy’s Laboratories issues an update on the Sputnik V vaccine in India.
Joint statement issued by RDIF and Dr. Reddy's Laboratories
28th may, 2021
In the last few days, there have been several unsubstantiated reports and claims from various quarters in India on alleged tie-ups for the Sputnik V vaccine.
Beware of unauthorised individuals offering fake deals or procurement of the Sputnik V vaccine.
Sputnik V soft launched in Hyderabad
14th may, 2021
Sputnik V soft launched in Hyderabad on 14 May 2021 to start testing of cold chain logistics with 2-dose regime.
Dr. Reddy’s partnership with RDIF
“The vaccine produced in India will be initially used to inoculate the country’s citizens; it will cater to the RDIF’s global requirements as volumes rise.”
DEEPAK SAPRA
CEO API AND SERVICES
Dr. Reddy’s Laboratories
Under emergency use authorisation for COVID-19 Pandemic. For public information only. Taking Sputnik is your choice. Please consult your physician for any questions about this vaccine.
References:
- LogunovDY et al. Gam-COVID-Vac Vaccine Trial Group. Lancet. 2021 Feb 20;397(10275):671-681
- https://sputnikvaccine.com/partnerships/
- https://www.pharmaceutical-technology.com/news/russia-covid-19-vaccine/
- https://sputnikvaccine.com/about-vaccine/
- https://www.who.int/news-room/feature-stories/detail/the-race-for-a-covid-19-vaccine-explained
- https://sputnikvaccine.com/upload/List_of_clinical_trials_on_human_adenovirus-based_vector_vaccines.pdf
